BIOCHEMICAL STUDIES ON DIPHENHYDRAMINE (BENADRYL)
نویسندگان
چکیده
منابع مشابه
BIOCHEMICAL STUDIES ON DIPHENHYDRAMINE (BENADRYL*) IV. DEGRADATION OF BENADRYL BY TISSUE ENZYMESf
The excretion of unchanged Benadryl accounts for only a small portion of the total administered dose in man (1, 2). Indirect evidence for the presence of degradation products in tissues and urine was obtained with Benadryl labeled with radioactive carbon (3). The experiments reported here show that degradation is produced by tissue enzymes, resulting in a loss of the basic properties of Benadry...
متن کاملBIOCHEMICAL STUDIES ON DIPHENHYDRAMINE (BENADRYL*) II. DISTRIBUTION IN TISSUES AND URINARY EXCRETIONt
Benadryl has been used extensively as an antihistamine agent, but little is known concerning its mode of action or metabolic fate. It is rapidly absorbed, as shown by earlier blood level studies (l-3) and the fact that clinical effects are observed in less than an hour (4). This paper presents observations on the distribution of Benadryl in the rat, chosen for its resistance to the action of hi...
متن کاملBiochemical studies on diphenhydramine (benadryl) distribution in tissues and urinary excretion.
Benadryl has been used extensively as an antihistamine agent, but little is known concerning its mode of action or metabolic fate. It is rapidly absorbed, as shown by earlier blood level studies (l-3) and the fact that clinical effects are observed in less than an hour (4). This paper presents observations on the distribution of Benadryl in the rat, chosen for its resistance to the action of hi...
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During and following the production of shock by hemorrhage in the normal, suprareno-demedullated, and suprarenalectomized rat, the following significant changes in amino acid and carbohydrate metabolism have been observed. 1. In the intact, suprareno-demedullated, and suprarenalectomized rat there is a progressive rise in the whole blood and plasma amino acid nitrogen levels during and after a ...
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In a previous publication (1, Paper V of this series) the purification and properties of the inositol-cleaving enzyme were described. It was shown that a highly purified enzyme was obtained from rat kidneys which cleaved inositol to D-ghCUI’OniC acid. The purified enzyme was shown to possess SH groups and 1 gram atom of iron per mole of enzyme. Both the SH groups and the iron are necessary for ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1949
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)56851-4